Rangers played out a 1-1 draw with Saoura FC away in Algeria last weekend and need at least a goal-less draw to qualify for the next round of the competition.
Rangers are the Nigeria Pro-Football League champions.
Nigeria’s second representative in the competition, Rivers United will also play AS Real Bamako in the second leg of their tie.
The first leg in Mali finished in a goalless draw.
In other fixtures, AS Port-Louis 2000 host Kenyan side Tusker while Al Ahli Tripoli play Wa All Stars
AS Vita Club are up against Royal Leopards of Swaziland.