Mark Hughes has been sacked as Southampton manager after eight months of being in charge.
The Saints, who drew with Manchester United in the Premier League on Saturday, are 18th in the table.
Southampton confirmed the move in a statement, adding: “The search for a new manager to take the club forward is already under way.”
First-team assistant coach Kelvin Davis will take charge of the team for the game against Tottenham on Wednesday.
Hughes, who also had a spell at the south coast club during his playing career, joined Southampton in March, two months after being sacked by Stoke City.